I use a flex shaft dremel on epoxies and resins for hours on end with sculpting. Grinding, cutting, sanding, etc., you name it.
After a lot of sinus issues, I'm a bit of a nut in terms of lung safety, so after trying a host of different methods, I ended up installing a vented blower in the bench as a dust system. I'm not suggest you go that far unless you plan on serious use, but an alternative is either grinding in you spray booth or setting up a shop vac so it draws rigt at the point of the work.
Downside of the shop vac is it's loud and you'll need a good filter, but if you're only going for short spurts, it's tolerable. I grind stuff daily for long periods, so I needed something quiet and efficient. I ended up getting an ash vacuum for the shop, which made a huge difference too. My run of the mill shop vac was just re-broadcasting dust. I'd wheeze after a good cleaning session.
The main thing to realize is, even with using a respirator, the dust is fine and going everywhere. So you may not be breathing it right then, but you will be for the next few months every time you move something, that's why a collection methd is key.
I had the aha moment when I was gringing under magnification and saw how much stuff is getting airborne.
In terms of respirators, cured resin isn't an OV, it's just an irritant, so a good N95 particulate cartridge is all you need. Main concern is fit. If going long term, 3M makes a 6000 series that is real comfortable and relatively inexpensive (I think about $12 on Amazon), which you can add all sorts of cartridges to. I have one just for grinding with a dual N95. It's easy to breathe through, unlike the cheap paper masks.